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J Med Microbiol 55 (2006), 1413-1418; DOI: 10.1099/jmm.0.46575-0
© 2006 Society for General Microbiology
ISSN 1473-5644

Predominance of multi-drug-resistant LAM and Beijing family strains among Mycobacterium tuberculosis isolates recovered from prison inmates in Tula Region, Russia

Anna Ignatova1, Svetlana Dubiley1, Valentina Stepanshina2 and Igor Shemyakin2

1 Shemyakin-Ovchinikov Institute of Bioorganic Chemistry, Moscow, Russia

2 State Research Center for Applied Microbiology, Obolensk, Moscow region, Russia

Correspondence
Svetlana Dubiley
lana{at}ibch.ru

Received 12 February 2006
Accepted 14 June 2006

The genotypic characteristics and drug susceptibility profiles of clinical isolates of Mycobacterium tuberculosis recovered from prison hospital patients in the Tula region (central Russia) during 2001 and 2002 are reported. The emergence of multi-drug-resistant tuberculosis (TB) poses a major health risk to the population, with economic implications for TB control. Prisons serve as a continuous source of TB transmission. The results showed that members of the LAM and Beijing families are major contributors to the epidemiological picture of TB in the population studied. The two families of strains accounted for most of the drug-resistant TB in the population. The genotypic characteristics of the M. tuberculosis predominant LAM strain that was responsible for 31 % of TB cases in this setting are presented.

Abbreviations: ASD-PCR, allele-specific depletory PCR; ETR, exact tandem repeat; FP, fingerprint pattern; MDR, multi-drug resistant; PGG, principal genetic group; RRDR, rifampicin resistance-determining region; ST, shared type; TB, tuberculosis.

Tables showing sequences of primers used, drug resistance profile and genotypic characteristics of the M. tuberculosis isolates and prevalence of drug resistance according to spoligofamily and case category and a figure showing identification of principal genetic groups using ASD-PCR are available as supplementary material in JMM Online.




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